Stop Employees transporting sensitive information home on USB keys The route you need to go down depends on whether your want to completely block USB drives or not. To disable USB drives, log onto the machine in question and launch the Registry Editor
3. type in: regedit
USBSTOR and double-click the key named Start in the right-hand pane.
Change the value of this key to 4 and USB storage devices will have been disabled. Your other option is to make USB drives read-only so that no files can be copied from your computers to them.
Log onto the machine you’d like to restrict, open up the Registry Editor and navigate to: